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Polyglycosaminoglycans (PGAs) are naturally occurring
substances found to alleviate symptoms associated with
osteo-arthritis. These substances work directly
in the joints. As an important part of joint fluid
production, PGAs act to increase the production of joint
fluid, making it easier for the joint surface to glide
upon itself.
Oxygen free radicals are also an important part of
osteo-arthritis, and can perpetuate the disease.
Oxygen free radicals actually can promote the breakdown
of the joint surface, and result in its degeneration.
PGAs act to bind to free radicals and help carry them
out of the body, thus preventing further damage to the
joints.
When taken by mouth, PGAs can take a few weeks to a
few months to show signs of improvement. Some
patients respond quite well to their effects while others
show little signs of improvement. There are no known
side effects to these agents so experimenting with them
in patients with arthritis is commonly done.
If benefits are seen, continuing the medication indefinitely
is recommended. If however, after a course of
a few months with no improvement, discontinuing the
PGAs would then be advised.
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